Peptide Synthesis

2009

2008

E. Leupold, H. Nikolenko, M. Beyermann, and M. Dathe. Insight into the role of HSPG in the cellular uptake of apolipoprotein E-derived peptide micelles and liposomes. Biochimica et Biophysica Acta-Biomembranes 1778 (12):2781-2789, 2008.

O. Pless, E. Kowenz-Leutz, M. Knoblich, J. Lausen, M. Beyermann, M. J. Walsh, and A. Leutz. G9a-mediated lysine methylation alters the function of CCAAT/enhancer-binding protein-beta. Journal of Biological Chemistry 283 (39):26357-26363, 2008.

I. Coin, M. Beerbaum, P. Schmieder, M. Bienert, and M. Beyermann. Solid-phase synthesis of a cyclodepsipeptide: Cotransin. Organic Letters 10 (17):3857-3860, 2008.

X. Sun, M. Becker, K. Pankow, E. Krause, M. Ringling, M. Beyermann, B. Maul, T. Walther, and W. E. Siems. Catabolic attacks of membrane-bound angiotensin-converting enzyme on the N-terminal part of species-specific amyloid-beta peptides. European Journal of Pharmacology 588 (1):18-25, 2008.

S. Diel, M. Beyermann, J. M. N. Llorens, B. Wittig, and C. Kleuss. Two interaction sites on mammalian adenylyl cyclase type I and II: modulation by calmodulin and G(beta gamma). Biochemical Journal 411:449-456, 2008.

S. Pritz, O. Kraetke, A. Klose, J. Klose, S. Rothemund, K. Fechner, M. Bienert, and M. Beyermann. Synthesis of protein mimics with nonlinear backbone topology by a combined recombinant, enzymatic, and chemical synthesis strategy. Angewandte Chemie-International Edition 47 (19):3642-3645, 2008.

I. Coin, P. Schmieder, M. Bienert, and M. Beyermann. The depsipeptide technique applied to peptide segment condensation: Scope and limitations. Journal of Peptide Science 14 (3):299-306, 2008.

D. Kaden, L. M. Munter, M. Joshi, C. Treiber, C. Weise, T. Bethge, P. Voigt, M. Schaefer, M. Beyermann, B. Reif, and G. Multhaup. Homophilic interactions of the amyloid precursor protein (APP) ectodomain are regulated by the loop region and affect beta-secretase cleavage of APP. Journal of Biological Chemistry 283 (11):7271-7279, 2008.

V. Hagen, B. Dekowski, N. Kotzur, R. Lechler, B. Wiesner, B. Briand, and M. Beyermann. {7-[bis(carboxymethyl)amino]coumarin-4-yl}methoxycarbonyl derivatives for photorelease of carboxylic acids, alcohols/phenols, thioalcohols/thiophenols, and amines. Chemistry-A European Journal 14 (5):1621-1627, 2008.

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2007

Klammt C, Srivastava A, Eifler N, Junge F, Beyermann M, Schwarz D, Michel H, Doetsch V, Bernhard F. Functional analysis of cell-free-produced human endothelin B receptor reveals transmembrane segment 1 as an essential area for ET-1 binding and homodimer formation. FEBS J. 274, 3257-3269 (2007).

Beyermann M, Heinrich N, Fechner K, Furkert J, Zhang W, Kraetke O, Bienert M, Berger H. Achieving signalling selectivity of ligands for the corticotropin-releasing factor type 1 receptor by modifying the agonist's signalling domain. Br J Pharmacol 151, 851-859 (2007)

Berger H, Heinrich N, Wietfeld D, Bienert M, Beyermann M. Evidence that corticotropin-releasing factor receptor type 1 couples to Gs- and Gi-proteins through different conformations of its J-domain. Brit J Pharmacol 149, 942-947 (2006)

Coin I, Schmieder P, Bienert M, Beyermann M, Pritz S, Wolf Y, Kraetke O, Klose J, Bienert M, Beyermann M. The depsipeptide technique applied to peptide segment condensation: scope and limitations. J Pept Sci 14, 299-306 (2007)

Pritz S, Wolf Y, Kraetke O, Klose J, Bienert M, Beyermann M. Synthesis of biologically active peptide nucleic acid-peptide conjugates by sortase-mediated ligation. J Org Chem 72, 3909-3912 (2007)

Coin I, Beyermann M, Bienert M. Solid-phase peptide synthesis: from standard procedures to the synthesis of difficult sequences. Nat Protoc 2, 3247-3256 (2007)

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2006

Przezdziak J, Tremel S, Kretzschmar I, Beyermann M, Bienert M, Volkmer-Engert R. Probing the ligand-binding specifity and analyzing the folding state of SPT-synthesized FBP28WW domain variants. Chembiochem 7, 1-9 (2006).

Coin I, Dölling R, Krause E, Bienert M, Beyermann m, Sferdean CD, Carpino LA. The depsipeptide methodology for solid phase peptide synthesis: circumventing side reactions and development of an automated technique via depsidipeptide units. J Org Chem 71, 6171-6177 (2006)

Berger H, Heinrich N, Wietfeld D, Bienert M, Beyermann M. Evidence that corticotropin-releasing factor receptor type 1 couples to Gs- and Gi-proteins through different conformations of its J-domain. Brit J Pharmacol 149, 942-947 (2006)

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2005

Klose J, Fechner K, Beyermann M, Krause E, Wendt N, Bienert M, Rudolph R, Rothemund S. Impact of N-terminal domains for corticotrpoin-releasing factor (CRF) receptor lignad interactions. Biochemistry 44, 1614-1623 (2005).

Mason AJ, Lopez JJ, Beyermann M, Glaubitz C. A spectroscopic study of the membrane interaction of tuberoinfundibular peptide of 39 residues (TIP 39). Biochemi Biophys Acta 1714, 1-10 (2005)

Tremmel S, Beyermann M, Oschkinat H, Bienert M, Naumann D, Fabian H. (13)C-Labeled Tyrosine Residues as Local IR Probes for Monitoring Conformational Changes in Peptides and Proteins. Angew Chem Int Ed 44, 4631-4635 (2005)

Kraetek O, Wiesner B, Eichhorst J, Furkert J, Bienert M, Beyermann M. Dimerization of Corticotropin-releasing factor receptor type 1 is not coupled to ligand binding. J Recept Signal Transduct Res 25, 251-276 (2005)

Kraetke O, Holeran B, Berger H, Escher E, Bienert M, Beyermann M. Photoaffinity cross-linking of the corticotropin-releasing factor receptor type 1 with photoreactive urocortin analogues. Biochemistry 44, 15569-77 (2005)

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Publications 2000-2004
Peptide Synthesis

2004

Carpino LA, Krause E, Sferdean CD, Schümann M, Fabian H, Bienert M, Beyermann M. Synthesis of “Difficult” Peptide Sequences : Application of a Depsipeptide Technique to the Jung-Redemann 10- and 26-mers and the Amyloid Peptide Abeta(1-42). Tetrahedron Lett. 45, 7519-23 (2004).

Carpino LA, Krause E, Sferdean CD, Bienert M, Beyermann M. Dramatically enhanced N to O acyl migration during the trifluoracetic acid-based deprotection step in solid phase peptide synthesis. Tetrahedron Lett. 46, 1361-1364 (2004)

Censarek P, Beyermann M, Koch KW. Thermodynamics of apocalmodulin and nitric oxide synthase II peptide inteaction. FEBS Lett. 577, 465-468 (2004)

Gregan  B, Jurgensen J, Papsdorf G, Furkert J, Schaefer M, Beyermann M, Rosenthal W, Oksche A. Ligand-dependent differences in the internalization of endothelin A and endothelin B receptor heterodimers. J. Biol. Chem. 279, 27679-87 (2004)

Henn V, Edemir B, Stefan E, Wiesner B, Lorenz D, Theilig F, Schmitt R, Vossebein L, Tamma G, Beyermann M, Krause E, Herberg FW, Valenti G, Bachmann S, Rosenthal W, Klussmann E. Identification of a novel A-kinase anchoring protein 18 isoform and evidence for its role in the vasopressin-induced aquaporin-2 shuttle in renal principal cells. J. Biol. Chem. 279, 26654-2665 (2004)

Klose J, Wendt N, Kubald S, Krause E, Fechner K, Beyermann M, Bienert M, Rudolph R, Rothemund S. Hexa-histidin tag position influences disulfide structure but not binding behavior of in vitro folded N-terminal domain of rat corticotropin-releasing factor receptor type 2a. Protein Sci. 13, 2470-75 (2004)

Schmidt A, Utepbergenov DI, Mueller SL, Beyermann M, Schneider-Mergener J, Krause G, Blasig IE. Occludin binds to the SH3-hinge-GuK unit of zonula occludens protein 1: potential mechanism of tight junction regulation. Cell. & Molec. Life Sciences 61, 1353-65 (2004)

Wietfeld D, Heinrich N, Furkert J, Fechner K, Beyermann M, Bienert M, Berger H.
Regulation of the coupling to different G proteins of rat corticotropin-releasing factor receptor type 1 (rCRFR1) in HEK cells. J Biol Chem 279, 38386-38394 (2004)

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2003

Carpino,L.A., Imazumi,H., El Faham,A., Fernando,J.F., Zhang,C., Lee,Y., Foxman,B.M., Henklein,P., Hanay,C., Mugge,C., Wenschuh,H., Klose,J., Beyermann,M., & Bienert,M. The uronium/guanidinium peptide coupling reagents: Finally the true uronium salts. Biopolymers 71, 349 (2003)

Carpino,L.A., Ionescu,D., El Faham,A., Beyermann,M., Henklein,P., Hanay,C., Wenschuh,H., & Bienert,M.
Complex polyfluoride additives in Fmoc-amino acid fluoride coupling processes. Enhanced reactivity and avoidance of stereomutation.
Organic Letters 5, 975-977 (2003)

Dathe,M., Nikolenko,H., Wessolowski,A., Schmieder,P., Beyermann,M., & Bienert,M. The membrane activity and selectivity of linear and cyclic hexapeptides. Journal of Liposome Research 13, 58 (2003).

Eggelkraut-Gottanka,R., Klose,A., Beck-Sickinger,A.G., & Beyermann, M.
Peptide (alpha)thioester formation using standard Fmoc-chemistry.
Tetrahedron Letters 44, 3551-3554 (2003).

Kaupp,U.B., Solzin,J., Hildebrand,E., Brown,J.E., Helbig,A., Hagen,V., Beyermann,M., Pampaloni,F., & Weyand,I.
The signal flow and motor response controling chemotaxis of sea urchin sperm.
Nature Cell Biology 5, 109-117 (2003)

Oksche,A., Grantcharova,E., Reusch,H.P., Furkert,J., Beyermann,M., & Rosenthal,W.
Ligand-induced N-terminal proteolysis of the endothelin B receptor: Role and fate of the cleaved N-terminal peptide. Naunyn-Schmiedebergs
Archives of Pharmacology 367, R18 (2003)

Otte,L., Wiedemann,U., Schlegel,B., Pires,J.R., Beyermann,M., Schmieder,P., Krause,G., Volkmer-Engert,R., Schneider-
Mergener,J., & Oschkinat,H.
WW domain sequence activity relationships identified using ligand recognition propensities of 42 WW domains.
Protein Science 12, 491-500 (2003).

Wietfeld,D., Fechner,K., Heinrich,N., Seifert,R., Bienert,M., & Beyermann,M.
Development of CRF receptor-2 selective peptide ligands.
Biopolymers 71, 376 (2003).

Wissmann,R., Bildl,W., Oliver,D., Beyermann,M., Kalbitzer,H.R., Bentrop,D., & Fakler,B.
Solution structure and function of the "Tandem inactivation domain" of the neuronal A-type potassium channel Kv1.4. Journal of Biological Chemistry 278 , 16142-16150 (2003).

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2002

Blomenrohr,M., ter Laak,T., Kuhne,R., Beyermann,M., Hund,E., Bogerd,J., & Leurs,R. Chimaeric gonadotropin-releasing hormone (GnRH) peptides with improved affinity for the catfish (Clarias gariepinus) GnRH receptor. Biochemical Journal 361, 515-523 (2002).

Carpino,L.A., Imazumi,H., El Faham,A., Ferrer,F.J., Zhang,C.W., Lee,Y.S., Foxman,B.M., Henklein,P., Hanay,C., Mugge,C., Wenschuh,H., Klose,K., Beyermann,M., & Bienert,M.
The uronium/guanidinium peptide coupling reagents: Finally the true uronium salts.
Angewandte Chemie-International Edition 41, 442-445 (2002).

Censarek,P., Beyermann,M., & Koch,K.W.
Target recognition of apocalmodulin by nitric oxide synthase I peptides.
Biochemistry 41, 8598-8604 (2002).

Dathe,M., Nikolenko,H., Beyermann,M., & Bienert,M.
Cyclization increases the antimicrobial activity and selectivity of tryptophan and arginine containing hexapeptides.
Biophysical Journal 82, 561A (2002).

Duda,T., Koch,K.W., Venkataraman,V., Lange,C., Beyermann,M., & Sharma,R.K.
Ca2+ sensor S100 beta-modulated sites of membrane guanylate cyclase in thephotoreceptor-bipolar synapse.
 Embo Journal 21, 2547-2556 (2002).

Grantcharova,E., Furkert,J., Reusch,H.P., Krell,H.W., Papsdorf,G., Beyermann,M., Schulein,R., Rosenthal,W., & Oksche,A.
The extracellular N terminus of the endothelin B (ETB) receptor is cleaved by a metalloprotease in an agonist-dependent process. Journal of Biological Chemistry 277, 43933-43941 (2002).

Oehlke,J., Birth,P., Klauschenz,E., Wiesner,B., Beyermann,M., Oksche,A., & Bienert,M. Cellular uptake of antisense oligonucleotides after complexing or conjugation with cell-penetrating model peptides.
European Journal of Biochemistry 269, 4025-4032 (2002).

Oksche,A., Grantcharova,E., Furkert,J., Beyermann,M., Papsdorf,G., & Rosenthal,W.
Ligand-induced proteolysis of the extracellular N-terminus of the human endothelin B (ETB) receptor.
Naunyn-Schmiedebergs Archives of Pharmacology 365, R16 (2002).

Sharma,R.K., Venkataraman,V., Lange,C., Beyermann,M., Koch,K.W., & Duda,T.
Biochemical and functional characterization of ROS-GC transduction system in the photoreceptor-bipolar neurons.
Investigative Ophthalmology & Visual Science 43, U1035 (2002).

Wieprecht,T., Beyermann,M., & Seelig,J.
Thermodynamics of the coil-alpha-helix transition of amphipathic peptides in a membrane environment: the role of vesicle curvature.
Biophysical Chemistry 96, 191-201 (2002).

Wiltfang,J., Esselmann,H., Bibl,M., Smirnov,A., Otto,M., Paul,S., Schmidt,B., Klafki,H.W., Maler,M., Dyrks,T., Bienert,M., Beyermann,M., Ruther,E., & Kornhuber,J.
Highly conserved and disease-specific patterns of carboxyterminally truncated A beta peptides 1-37/38/39 in addition to 1-40/42 in Alzheimer's disease and in patients with chronic neuroinflammation.
Journal of Neurochemistry 81, 481-496 (2002).

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2001

Bentrop,D., Beyermann,M., Wissmann,R., & Fakler,B.NMR structure of the "ball-and-chain" domain of KCNMB2, the beta(2)-subunit of large conductance Ca2+ and voltage-activated potassium channels. Journal of Biological Chemistry 276, 42116-42121 (2001).

Dathe,M., Nikolenko,H., Meyer,J., Beyermann,M., & Bienert,M.
Optimization of the antimicrobial activity of magainin peptides by modification of charge.
Febs Letters 501, 146-150 (2001).

Fischer,T., Beyermann,M., & Koch,K.W.
Application of different surface plasmon resonance biosensor chips to monitor the interaction of the CaM-binding site of nitric oxide synthase I and calmodulin.
 Biochemical and Biophysical Research Communications 285, 463-469 (2001).

Helluin,O., Beyermann,M., Leuchtag,H.R., & Duclohier,H.
A critical role for the branched sidechain adjacent to the third arginine of the sodium channel voltage sensor.
 Ieee Transactions on Dielectrics and Electrical Insulation 8, 637-643 (2001).

Janek,K., Rothemund,S., Gast,K., Beyermann,M., Zipper,J., Fabian,H., Bienert,M., & Krause,E.
Study of the conformational transition of A beta(1-42) using D-amino acid replacement analogues.
Biochemistry 40, 5457-5463 (2001).

Salmon,A.L., Cross,L.J.M., Irvine,A.E., Lappin,T.R.J., Dathe,M., Krause,G., Canning,P., Thim,L., Beyermann,M., Rothemund,S., Bienert,M., & Shaw,C.
Peptide leucine arginine, a potent immunomodulatory peptide isolated and structurally characterized from the skin of the Northern Leopard frog, Rana pipiens.
Journal of Biological Chemistry 276, 10145-10152 (2001).

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2000

Wiltfang,J., Esselmann,H., Cupers,P., Neumann,M., Kretzschmar,H., Beyermann,M., Schleuder,D., Jahn,H., Ruther,E., Kornhuber,J., Annaert,W., De Strooper,B., & Saftig,P. Elevation of beta-amyloid peptide 2-42 in sporadic and familial Alzheimer's disease and its generation in PS1 knockout cellsJournal of Biological Chemistry 276, 42645-42657 (2001).

Beyermann,M., Rothemund,S., Heinrich,N., Fechner,K., Furkert,J., Dathe,M., Winter,R., Krause,E., & Bienert,M.
A role for a helical connector between two receptor binding sites of a long-chain peptide hormone.
Journal of Biological Chemistry 275 , 5702-5709 (2000).

Dathe,M., Nikolenko,H., Gumpert,J., Beyermann,M., & Bienert,M.
Charge based differences in the interaction of margin II peptides with cell membranes and lipid bilayers.
Biophysical Journal 78, 322A (2000).

Oksche,A., Boese,C., Horstmeyer,A., Papsdorf,G., Furkert,J., Beyermann,M., Bienert,M., & Rosenthal,W.
Evidence for downregulation of the endothelin-B-receptor by the use of fluorescent endothelin-1 and a fusion protein consisting of the endothelin-B-receptor and the green fluorescent protein.
Journal of Cardiovascular Pharmacology 36, S44-S47 (2000).

Oksche,A., Boese,G., Horstmeyer,A., Furkert,J., Beyermann,M., Bienert,M., & Rosenthal,W.
Late endosomal/lysosomal targeting and lack of recycling of the ligand-occupied endothelin B receptor.
Molecular Pharmacology 57, 1104-1113 (2000).

Wieprecht,T., Apostolov,O., Beyermann,M., & Seelig,J.
Interaction of a mitochondrial presequence with lipid membranes: Role of helix formation for membrane binding and perturbation.
Biochemistry 39, 15297-15305 (2000).

Wieprecht,T., Apostolov,O., Beyermann,M., & Seelig,J.
Membrane binding and pore formation of the antibacterial peptide PGLa: Thermodynamic and mechanistic aspects.
Biochemistry 39, 442-452 (2000).

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Book contributions

M. Beyermann, M. Bienert & L.A. Carpino. Acid Halides.
in Houben-Weyl, Methods of Organic Chemistry, 4^th Edition
Georg Thieme Verlag Stuttgart, New York, Eds.: M. Goodman, A. Felix, L. Moroder & C. Toniolo, Chapt. 3.3, pp. 475-494, 2002.

M. Bienert, P. Henklein, M. Beyermann & L.A. Carpino. Uronium/Guanidinium Salts.
in Houben-Weyl, Methods of Organic Chemistry, 4^th Edition
Georg Thieme Verlag Stuttgart, New York, Eds.: M. Goodman, A. Felix, L. Moroder & C. Toniolo, Chapt. 3.8, pp. 555-580, 2002.

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