Protein Engineering (Christian Freund)
Publications Group Freund
2009
Lehmann R, Meyer J, Schuemann M, Krause E, Freund C.
A novel S3S-TAP-tag for the isolation of T cell interaction partners of adhesion and degranulation promoting adaptor protein (ADAP)
Proteomics [Epub ahead of print] (October 1th 2009).
Schlundt A, Sticht J, Piotukh K, Kosslick D, Jahnke N, Keller S, Schuemann M, Krause E, Freund C.
Proline-rich sequence recognition II: proteomic analysis of TSG101-UEV interactions.
Mol. Cell. Proteom., advanced online publication (June 20th 2009).
Kofler, M., Schümann, M., Merz, C., Kosslick, D., Schlundt, A., Tannert, A. Schaefer, M., Lührmann, R., Krause, E. and Freund, C.
Proline-rich sequence recognition I: Marking GYF and WW domain assembly sites in early spliceosomal complexes.
Mol. Cell. Proteom., advanced online publication (May 30th 2009).
Schlundt, A., Kilian, W., Beyermann, M., Sticht, J., Günther, S., Höpner, S., Falk, K., Rötzschke, O., Mitschang, L. and Freund, C.
A Xenon-129 biosensor for monitoring MHC-peptide interactions.
Angew Chem Int Ed Engl. 2009;48(23):4142-5.
2008
Ueffing N, Keil E, Freund C, Kühne R, Schulze-Osthoff K, Schmitz I.
Mutational analyses of c-FLIP(R), the only murine short FLIP isoform, reveal requirements for DISC recruitment.
Cell Death Differ. 2008 Jan 25.
Rathert, P., Zang, X., Freund, C., Cheng, X. & Jeltsch, A.
Analysis of the substrate specificity of the Dim-5 histone lysine methyltransferases using peptide arrays.
Chem Biol. 2008 Jan;15(1):5-11.
Uryga-Polowy, V., Kosslick, D., Freund, C. & Rademann, J.
Resin-bound aminofluorescein for C-terminal labeling of peptides: high-affinity polarization probes binding to polyproline-specific GYF domains.
Chembiochem. 2008 Oct 13;9(15):2452-62.
Freund C, Schmalz HG, Sticht J, & Kühne R.
Proline-Rich Sequence Recognition Domains (PRD): Ligands, Function and Inhibition.
Handb Exp Pharmacol. 186:407-429, Springer.
Heinze, M. & Freund, C.
The T cell receptor.
Encyclopedia of Experimental Pharmacology, Springer.
2007
Heinze M, Kofler M, Freund C.
Investigating the functional role of CD2BP2 in T cells.
Int Immunol. 2007 Nov;19(11):1313-8.
Piotukh K, Kosslick D, Zimmermann J, Krause E, Freund C.
Reversible disulfide bond formation of intracellular proteins probed by NMR spectroscopy.
Free Radic Biol Med. 2007 Nov 1;43(9):1263-70.
Zimmermann J, Kuhne R, Sylvester M, Freund C.
Redox-regulated conformational changes in an SH3 domain.
Biochemistry. 2007 Jun 12;46(23):6971-7.
2006
Hopner S, Dickhaut K, Hofstatter M, Kramer H, Ruckerl D, Soderhall JA, Gupta S, Marin-Esteban V, Kuhne R, Freund C, Jung G, Falk K, Rotzschke O.
Small organic compounds enhance antigen loading of class II major histocompatibility complex proteins by targeting the polymorphic P1 pocket.
J Biol Chem. 2006 Dec 15;281(50):38535-42.
Kliche, S., Breitling, D., Togni, M., Pusch, R., Heuer, K., Wang, X., Freund, C., Kasirer-Friede, A., Menasche, G., Koretzky, G.A. and Schraven, B.
The ADAP/SKAP55 Signaling Module Regulates T-Cell Receptor-Mediated Integrin Activation through Plasma Membrane Targeting of Rap1.
Mol Cell Biol. 2006 Oct;26(19):7130-44.
Heuer, K., Sylvester, M., Kliche, S., Pusch, R., Thiemke, K., Schraven, B. and Freund, C.
Lipid-binding hSH3 domains in immune cell adapter proteins.
J Mol Biol. 2006 Aug 4;361(1):94-104.
Kofler, M.M. and Freund, C.
The GYF domain.
FEBS J. 2006 Jan;273(2):245-56.
2005
Kofler M, Motzny K, Freund C.
GYF domain proteomics reveals interaction sites in known and novel target proteins.
Mol Cell Proteomics. 2005 Nov;4(11):1797-811
Zimmermann, J. and Freund, C.
NMR assignment of the reduced and oxidized forms of the human ADAP hSH3-1 domain.
J Biomol NMR. 2005 May;32(1):94.
Gu, W., Kofler, M., Antes, I., Freund, C., and Helms, V.
Alternative Binding Modes of Proline-rich Peptides Binding to the GYF Domain. Biochemistry. 2005 May 3;44(17):6404-15.
Heuer, K., Arbuzova, A., Strauss, H., Kofler, M., and Freund, C.
The helically extended SH3 domain of the T cell adaptor protein ADAP is a novel lipid interaction domain.
J Mol Biol. 2005 May 13;348(4):1025-35.
Piotukh, K. Gu, W., Kofler, M., Labudde, D., Helms, V.and Freund, C.
Cyclophilin A binds to linear peptide motifs containing a consensus that is present in many human proteins.
J Biol Chem. 2005 Jun 24;280(25):23668-74.
Pahlke, D., Freund, C., Leitner, D. and Labudde, D.
Statistically significant dependence of the Xaa-Pro peptide bond conformation on secondary structure and amino acid sequence.
BMC Struct Biol. 2005 Apr 1;5:8.
Kofler M, Motzny K, Beyermann M, Freund C.
Novel interaction partners of the CD2BP2-GYF domain.
J Biol Chem. 2005 Sep 30;280(39):33397-402.
2004
Heuer, K., Kofler, M. Langdon, M., Thiemke, K. and Freund, C.
Structure of a helically extended SH3 domain of the T cell adapter protein ADAP.
Structure. 2004 Apr;12(4):603-10.
Kofler, M., Heuer, K., Zech, T., Thiemke, K. and Freund, C.
Recognition sequences for the GYF domain reveal a possible spliceosomal function of CD2BP2.
J Biol Chem. 2004 Jul 2;279(27):28292-7.
Freund, C.
The GYF domain
Modular Protein Domains, 103-116, Wiley-VCH GmbH, Germany
ISBN 3-527-30799-0
Book Contributions
Freund, C.
The GYF domain
Modular Protein Domains, 103-116, Wiley-VCH GmbH, Germany
ISBN 3-527-30799-0
