Structural Bioinformatics and Protein Design
(Gerd Krause)

Research

The group is focused on sequence-structural analysis of proteins by structural bioinformatics combined with experimental functional studies of changed sequence(s) to reveal sequence- and structure- function relationships of proteins. The main aim is rational discovery of molecular mechanisms and sites for protein-protein interactions and protein-ligand interaction. Locations for potential pharmacological intervention are narrowed down to the amino acid and atom level by predicting functional sensitive residues or atoms that are subsequently experimentally evaluated such as by side directed mutagenesis or peptide mapping. All group project lines are characterized either by own verification or by close cooperation with experimental partners within the FMP and from universities to ensure a closed loop between theoretically derived model and experimental proof.