Structural Genomics (Linda Ball)

The Biomolecular NMR group focuses on using NMR spectroscopy to obtain high resolution structural information on human proteins and their complexes. We also use NMR for screening of targeted small molecule libraries in the search for ligands and inhibitors.

Our primary interests are in using NMR for:

• Determination of the solution structures of small modular protein domains in solution.
• Determination of solution structures of proteins that can not be solved using X-ray crystallography.
• Studies of protein-peptide protein-protein and protein-small molecule interactions and, where possible, determining structures of the complexes.
• Investigations of local molecular dynamics on the NMR timescale and of protein self-association/oligomerization behaviour in solution.
• Identification and optimization of small molecule ligands using 1D and 2D NMR screening methods.