Research Groups
Coordinator: Hartmut Oschkinat
Department NMR-supported Structural Biology (Hartmut Oschkinat)
The Oschkinat lab focuses on the structural characterisation of protein-protein interactions responsible for the reception and transduction of signals in biological systems. We are interested in protein domains which recognise specific peptides and in membrane integrated receptors and receptor-ligand complexes.
Solution NMR (Peter Schmieder)
We use the full repertoire of solution state NMR techniques in conjunction with a variety of labelling patterns to address questions of biological and pharmacological importance. These range from the development of new techniques for solution state NMR to the elucidation of the constitution and configuration of biological active peptides and the determination of the three-dimensional structure of peptides and proteins.
Structural Bioinformatics (Gerd Krause)
We focus on the analysis of proteins by structural bioinformatics combined with experimental functional studies of changed sequence(s) to reveal sequence- and structure-function relationships of proteins. Our aim is the rational discovery of molecular mechanisms and sites for protein-protein interactions and protein-ligand interaction.
We are concerned with the study of protein-protein, protein-ligand interactions, and ligand design by computational algorithms. Our work involves a wide range of molecular modeling technologies, bioinformatics tools, and expertise in NMR structure calculations.
Structural Genomics (Linda Ball)
The structural Genomics group focuses on using NMR spectroscopy to obtain high resolution structural information on human proteins and their complexes. We also use NMR for screening of targeted small molecule libraries in the search for ligands and inhibitors.
Our group is interested in biomolecular systems that are situated at the interface between solution and solid. In this area, membrane proteins and amyloidogenic peptides and proteins are the most interesting "target molecules".
Protein Engineering (Christian Freund)
We are interested in the understanding and manipulation of molecular interactions that govern the assembly of protein complexes. The focus is on scaffolding proteins that mediate non-covalent interactions in immune cells and other eukaryotic cells.
We work at the interface of cell biology and biophysics to study the structural and functional in vivo properties of proteins inside cells. The main focus of the group is to learn about the structural characteristics of intrinsically unfolded proteins (IDPs) in their native cellular environments and about post-translational protein modifications and their influence on protein structure and function.
Molecular Imaging (Leif Schröder)
Our group works on the development of magnetic resonance detection techniques for novel targeted contrast agents.
